And that's really saying something.
The third baseman will hang up his spikes after this weekend's series in Boston, but he won't ever be forgotten. In a short Red Sox career, Lowell has left an impact that will live for years to come.
In the process, he's created many memories, and though there are too many to count, we're asking which of these three is your favorite:
Winning 2007 World Series MVP
Lowell batted .400 in the four-game series, hitting a homer, driving in four runs and stealing a base for good measure.
Hitting one of four consecutive homers against Yankees
Before the Sox were world champs in '07, they had to establish their power in the AL East. That started in April, when Lowell was part of the quartet that homered in back-to-back-to-back-to-back at-bats off Chase Wright.
With a national audience watching, Manny Ramirez, J.D. Drew, Lowell and Jason Varitek all hit homers, turning a 3-0 deficit into a 4-3 advantage.
Hitting homer in first at-bat coming off disabled list
This one is certainly near and dear to fans, as it happened just two months ago. Lowell had been out of the lineup due to injury since June 22, but he was able to return on Aug. 3.
The Fenway faithful, looking to show their collective admiration and appreciation for Lowell, rose to give him a standing ovation as he walked to the plate for his first at-bat.
The first pitch came, and Lowell homered. It was a moment that a veteran like Lowell will remember for a long time.
It's hard to pick just one, but which is your favorite Mike Lowell moment? If it's his World Series MVP performance, text "SOX1" to 542542. If it's the four straight homers against the Yanks, text "SOX2" to 542542. If it's the homer in the first pitch off the DL, text "SOX3" to 542542.