After going 2-for-7 and scoring three runs in Boston's first two games against Minnesota, Dustin Pedroia will be out of Wednesday night's lineup when the Sox go for the sweep.
Mike Aviles will instead get the start at second and will bat ninth. Aviles is 3-for-8 with a double and a triple against Twins starter Nick Blackburn.
Marco Scutaro, who will play shortstop after a night off, will move up to Pedroia's usual No. 2 spot in the order. Scutaro enters Wednesday with seven hits in his last eight at-bats.
Josh Reddick also returns to the lineup. He'll get the start in right field and bat eighth.
Jon Lester, who gets the nod for the Sox, is 1-2 in his career against the Twins with 28 strikeouts and a 4.67 ERA. Jarrod Saltalamacchia is back behind the plate.
Here's the rest of the lineups for both teams.
Red Sox
Jacoby Ellsbury, CF
Marco Scutaro, SS
Adrian Gonzalez, 1B
Kevin Youkilis, 3B
David Ortiz, DH
Carl Crawford, LF
Jarrod Saltalamacchia, C
Josh Reddick, RF
Mike Aviles, 2B
Twins
Denard Span, CF
Ben Revere, RF
Joe Mauer, C
Michael Cuddyer, 1B
Jim Thome, DH
Danny Valencia, 3B
Delmon Young, LF
Trevor Plouffe, 2B
Tsuyoshi Nishioka, SS
