Brady wasn't without help though, getting great performances from the likes of Rob Gronkowski, Wes Welker, Brandon Bolden and Stevan Ridley.
Gronkowski made a great catch on a rarely competed deep ball from Brady, but struggled for the remainder of the first half, letting a couple passes bounce off his hands. The Patriots' tight end came back in a big way in the second half, ending his day with five receptions for 104 yards and one touchdown.
Injured Julian Edelman wasn't missed thanks to Welker. The Patriots' slot receiver had a classic day at the office with nine receptions and 129 yards. Welker and Brady were on the same page all day, with only two targets going uncaught.
Ridley has been a man-possessed in 2012, and might be exactly what this offense needs to succeed in 2012 if he can keep being reliable. Ridley ran for 106 yards on 22 carries in a Corey Dillon-esque performance. Ridley is certainly built in the mold Bill Belichick seems to like in a running back.
Undrafted-rookie Bolden is also built from the Patriots-running back mold. He had his breakout performance running for 137 yards on 16 carries and flashed what so many people were raving about in training camp. Sunday was the first time since 1980 that the Patriots have had two 100-yard rushers in the same game.
So who had the most impressive performance in Buffalo?