Perhaps the most important matchup of the week comes on Sunday night when the Green Bay Packers go into Houston to take on the Texans.
Houston has been arguably the best team in the league this season, and they put their undefeated record on the line against a 2-3 Packers squad. The Pack is beat up with Cedric Benson possibly out for the year and concerns surrounding Jermichael Finley, and they're going to need to finally put things together to get back on the right track.
Here are this week's lines, courtesy of Bovada.
Pittsburgh (-6.5) at Tennessee
The Titans give up a lot of points, and they might do so again this week against a Pittsburgh offense that continues to get healthy.
Cincinnati (-3) at Cleveland
So how is Ohio State doing this year?
Indianapolis at New York Jets (-3)
Is this the last time the Jets will be favored to win a game all season? Perhaps, but unlikely, thanks to the Buffalo Bills.
Kansas City at Tampa Bay (-4)
Oakland at Atlanta (-9)
Matt Ryan and the Falcons look to run their record to 6-0 against a Raiders team that was torched by Peyton Manning a couple of weeks ago.
Dallas at Baltimore (-4)
This is not the team the Cowboys want to see coming out of their bye week, two weeks removed from a turnover-filled loss to the Bears.
Detroit at Philadelphia (-4)
The Underachiever Bowl.
St. Louis at Miami (-3.5)
Both teams have overachieved at times this season, and have been kind of ugly at others. Don't expect many points here, either.
New England (-4) at Seattle
The league's best offense goes on the road to take on the league's best defense in what could be the game of the week.
Buffalo at Arizona (-5)
The Bills, fresh off of giving up more than 600 yards last week, will get their chance to make Kevin Kolb and the Cardinals look like a legitimate NFL offense.
New York Giants at San Francisco (-4.5)
This matchup of last season's NFC Championship will be a nice measuring stick for the Giants, who are again a tough team to figure out.
Minnesota at Washington
This is a matchup of two of the best run defenses in football squaring off in a game in which both offenses will want to establish dominance on the ground.
Green Bay at Houston (-3)
The Packers are in desperate need of a season-turning win, while the Texans are out to prove they are indeed the cream of the NFL's crop.
Denver at San Diego (-1.5)
This AFC West showdown gives the country another chance to see that Manning guy play football. Finally!