49ers Vs. Panthers: Betting Line, Predictions For NFL Week 2 Game

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Editor’s note: NESN.com’s Mike Cole, Ricky Doyle and Andre Khatchaturian deliver their NFL picks every Thursday of the season, and here’s who they like in Sunday’s San Francisco 49ers-Carolina Panthers Week 2 game.

San Francisco 49ers (1-0) at (-13) Carolina Panthers (0-1), 1 p.m.
Mike: Panthers.
Pretty much everything in the world goes against the 49ers, who are playing on a short week and going to the East Coast for an early game against the defending conference champions, who had an extra three days of preparation.
Ricky: Panthers. The spread scares the crap out of me, given it’s early in the season and we still don’t really know either team’s true colors. That said, the 49ers’ Week 1 beatdown win was a product of the Rams’ incompetence, and the Panthers will have a chip on their shoulders in their home opener.
Andre: Panthers. Carolina has three extra days to prepare after a heartbreaking opening night loss to the Broncos. The 49ers played Monday night and will travel across the country. This is Cam Newton’s first home game since winning the NFC title. Think he’ll be pumped?

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Thumbnail photo via Sam Sharpe/USA TODAY Sports Images

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