NFL Picks: Cardinals Vs. Bills Week 3 Game Odds, Predictions

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Sep 25, 2016

Editor’s note: NESN.com’s Mike Cole, Ricky Doyle and Andre Khatchaturian deliver their NFL picks every Thursday of the season, and here’s who they like in the Arizona Cardinals-Buffalo Bills Week 3 game, with the line from OddsShark.

(-4) Arizona Cardinals (1-1) at Buffalo Bills (0-2), 1 p.m.
Mike: Bills. We’re really just fading the public here (more than 80 percent of bets currently are on the Cardinals), but this also feels like it could be Rex Ryan’s last stand. The Bills should lose, but they can keep it close.
Ricky: Cardinals. Rex Ryan said back-to-back games against the Cardinals and Patriots could be exactly what the 0-2 Bills need. Well, hopefully his résumé is ready, because he could hit the unemployment line once Buffalo falls to 0-4, starting this week when Arizona rolls.
Andre: Cardinals. Arizona continues to be a top-10 points-per-play team on offense (eighth) and on defense (seventh). The Bills only scored against the Jets last week because of some big plays by Tyrod Taylor against a leaky secondary. I don?t see Patrick Peterson, Tyronn Mathieu and Co. making those same mistakes.

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Thumbnail photo via Timothy T. Ludwig/USA TODAY Images

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