NFL Picks: Chargers Vs. Colts Week 3 Game Odds, Predictions

Editor’s note: NESN.com’s Mike Cole, Ricky Doyle and Andre Khatchaturian deliver their NFL picks every Thursday of the season, and here’s who they like in the San Diego Chargers-Indianapolis Colts Week 3 game, with the line from OddsShark.

San Diego Chargers (1-1) at (-2.5) Indianapolis Colts (0-2), 4:25 p.m.
Mike: Chargers. Both teams have been decimated by injuries, but the Colts’ inability to stop the run (4.5 yards per rush) is especially worrisome in this situation. The Chargers also are 5-0 against the spread in their last five; Indy is just 2-5 ATS in its last seven.
Ricky: Chargers. Andrew Luck sucked last week against the Broncos, but let’s face it: his supporting cast is brutal. And that includes the Colts’ dinged-up secondary, which Philip Rivers will have a field day with Sunday despite the Chargers dealing with injuries of their own.
Andre: Chargers. It?s amazing what a stout running game has done for Philip Rivers. Last season, he threw the ball 661 times (most in the NFL). This year, he has thrown it just 60 times (third fewest). Rivers is better, thanks to Melvin Gordon taking loads of pressure off him, and nothing the Colts have says they will slow down either of them.