Johnson plowed his way through the field in three laps to grab his first career victory at Bristol Motor Speedway and deny Kurt Busch a chance to gain more ground on the No. 48 championship team.
"When we're winning at tracks that we're not supposed to, boys better look out," Johnson warned. "Even that 2 car (Busch) that doesn't want the 48 to win."
Busch led 278 of the 500 laps and had a decent gap on Johnson when his easy drive to victory was clouded by a debris caution with 17 laps remaining. All the leaders headed to pit road, and Busch and Johnson both took four tires on the final stop.
Greg Biffle, Matt Kenseth, Carl Edwards and Tony Stewart all took two tires, giving them the first four positions on the restart. Busch was fifth, Johnson was sixth and the race resumed with 10 laps to go.
Kenseth's difficulty getting up to speed stacked up traffic behind him, including Busch, who lost his opportunity to leapfrog his way to the front.
Not Johnson, though. He weaved through the mess up to second, Stewart moved into the lead, and Johnson needed just over one lap to pick him off, too.
Busch, a five-time Bristol winner who hasn't been to Victory Lane at the bullring since 2006, was irate over his radio at the loss. He settled for third behind Johnson and Stewart, missing his chance to win his second consecutive race of the season and prove his Penske Racing team has made enough gains to run consistently with Johnson and the Hendrick Motorsports bunch.
"I'd rather lose to any of the other 41 cars out there than the 48 car," Busch said. "I thought we had him beat. I gave it my heart today, but we came up short."
It was Johnson's third win of the season and 50th of his career. More importantly, it was his first at Bristol, where his previous best finish in 16 starts was third. Nine of his previous finishes here had been outside the top 16.
"It's about time," Johnson said. "Been off here over the years, but we focused on what we had to do and overcame it."
At the start of each season, Johnson and crew chief Chad Knaus write down their goals and finally grabbing a checkered flag here was a big one.
"It was pretty high on his list," Knaus said. "For him to say that he wanted to focus on that and get better at this racetrack, for us to be able to go out there and do what we did, I think it speaks volumes about the dedication and desire he's got inside.
"We want to win every single event. This one has eluded us. We're very proud to be able to have it."
Next up for Johnson is Martinsville Speedway, where he's won five of the last seven races.
Biffle finished fourth and was followed by his Roush Fenway Racing teammates Kenseth and Edwards. Dale Earnhardt Jr. overcame a speeding penalty to finish seventh, Jamie McMurray was eighth and Kyle Busch and Jeff Burton rounded out the top 10.
Kevin Harvick maintained his lead in the Sprint Cup Series standings by finishing 11th.
Johnson became only the 12th driver in NASCAR history to win 50 races. He reached the milestone in his 296th start. Only three drivers did it faster: Jeff Gordon (232), Darrell Waltrip (278) and David Pearson (293).
Even with his stats, though, team owner Rick Hendrick doesn't think his driver gets his due.
"If you look at the stats and you look at the talent and you look at the dedication, just look at his record — I don't understand why it's not written now he's one of the best that's ever done this," Hendrick said. "You look at Jeff, and I've been around for a long time, I've watched a lot of guys from Richard Petty on up to current day.
"When you look at the level of competition since he's been in the sport, what he's done, what he's accomplished, I mean, I don't know what he's got to do."