The Red Sox will look to continue to make life miserable for Phil Hughes at Fenway Park when they meet the Yankees for the second of three games on Wednesday night.

The Yankees right-hander has struggled throughout his career at Fenway with an 8.83 ERA in seven career appearances in Boston.

The Boston lineup will look a little bit different on Wednesday night, as well. David Ortiz, who is a .467 (7-for-15) hitter against Hughes, has moved into the cleanup spot for the night. He takes that spot over from Dustin Pedroia, who will move back to his customary second spot in the lineup after spending the majority of the last couple of weeks filling in for Kevin Youkilis in the four-hole.

Josh Beckett will look to stay perfect against the Yankees this season, as the right-hander enters the matchup with a 3-0 record to go along with a 1.00 ERA against the Bombers this summer.

Jacoby Ellsbury, CF
Dustin Pedroia, 2B
Adrian Gonzalez, 1B
David Ortiz, DH
Jed Lowrie, 3B
Carl Crawford, LF
Josh Reddick, RF
Jason Varitek, C
Marco Scutaro, SS

New York
Brett Gardner, LF
Derek Jeter, SS
Curtis Granderson, CF
Mark Teixeira, 1B
Robinson Cano, 2B
Nick Swisher, RF
Eric Chavez, DH
Eduardo Nunez, 3B
Francisco Cervelli, C