Guillen will return to Florida following Monday's game at Philadelphia and apologize Tuesday at Marlins Park. The Phillies and Marlins are off Tuesday before the series resumes Wednesday.
Guillen had told Time magazine he loves the Cuban leader and respects him for staying in power so long. The manager said before Monday's game he's had sleepless nights because of his comments and wants to make amends.
"I'm going to make everything clear what's going on," he said. "People can see me and talk. I've already talked to people. But I think it's the proper thing to see my eyes. They can see me and ask whatever question they want. I think sooner is better. Better for the ballclub, better for me."
He apologized over the weekend after the story broke last week.
A Cuban-American group planned a demonstration Tuesday at the ballpark. The protest was organized before Guillen said he would fly to Miami.
"I know I hurt a lot of people," Guillen said. "I want to get the thing over with."
Guillen said the news conference would be open to "anybody that wants to be there."