Gomez replaces everyday DH David Ortiz, who was placed on the disabled list earlier on Wednesday. In eight games with the Sox this season, Gomez is hitting .308 with 3 RBIs. Cody Ross will hit in Ortiz' typical No. 3 hole in the order, as he returns to his normal place in right field after sitting for much of the game on Tuesday.
Jacoby Ellsbury and Carl Crawford will lead things off for the Sox for a third straight game, looking to welcome White Sox left-hander Pedro Hernandez to the big leagues for his major league debut. Hernandez was 7-2 with a 2.75 ERA in 12 starts at Double-A Birmingham this season.
Felix Doubront (9-4, 4.41) will get the start for the Red Sox, taking the mound for the first time since the All-Star break.
Check out the full lineups for both sides, below.
Red Sox (46-45)
Jacoby Ellsbury, CF
Carl Crawford, LF
Cody Ross, RF
Adrian Gonzalez, 1B
Will Middlebrooks, 3B
Mauro Gomez, DH
Mike Aviles, SS
Kelly Shoppach, C
Pedro Ciriaco, 2B.
Felix Doubront, LHP
White Sox (50-40)
Alejandro De Aza, CF
Kevin Youkilis, 3B
Adam Dunn, DH
Paul Konerko, 1B
Alex Rios, RF
A.J. Pierzynski, C
Dayan Viciedo, LF
Alexei Ramirez, SS
Gordon Beckham, 2B
Pedro Hernandez, LHP
