Skelton, who beat out Kevin Kolb in the preseason to earn the starting gig, suffered an ankle injury on Sunday in a loss to the Seattle Seahawks. According to ProFootballTalk.com, that low ankle sprain will keep Skelton out for 2-4 weeks.
That also means that it's likely that Kolb will be handed the keys as the club's starting quarterback this weekend against the Patriots.
Kolb, a second-round pick of the Eagles in 2007, struggled last season in his first year with Arizona. He made just nine starts — going 3-6 — while throwing for 1,955 yards, nine touchdowns and eight interceptions.
Kolb completed six of eight passes for 66 yards and a touchdown upon coming into the Cardinals' Week 1 loss to the Seahawks.
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