Patriots quarterback Tom Brady and Broncos QB Peyton ManningWhen you’ve dominated the NFL landscape for 15 years, you’ll probably make a rival or two along the way. That certainly has been the case for the New England Patriots en route to their four Super Bowl championships since the turn of the century.

One of the biggest constants in these rivalries has been the Mannings. Whether Peyton with the Indianapolis Colts or the Denver Broncos, or Eli with the New York Giants, New England has had plenty of big games against the quarterback brothers.

But their teams aren’t alone in the list of the Patriots’ biggest rivals of the past 15 years.

Click to see the Patriots’ five biggest rivals of the 2000s >>

Thumbnail photo via Twitter/@Trags