49ers Vs. Bills: Odds, Analysis, Picks For NFL Week 6 Game


Editor’s note: NESN.com’s Mike Cole, Ricky Doyle and Andre Khatchaturian deliver their NFL picks every Thursday of the season, and here’s who they like in the San Francisco 49ers-Buffalo Bills Week 6 game, with the line from OddsShark.

San Francisco 49ers (1-4) at (-7.5) Buffalo Bills (3-2), Sunday, 1 p.m. ET
Mike: Bills. The Niners aren’t publicly committing to any defensive adjustments, which might be an issue. San Fran’s rushing defense ranks 31st in the NFL and gets a potentially disastrous matchup against the Bills’ rushing attack, which ranks first in the NFL with 5.1 yards per rush.
Ricky: 49ers. Not expecting much from Colin Kaepernick, but he’s not Blaine Gabbert, and that’s a step in the right direction. In fact, let’s say the quarterback change is worth half a point and the Bills win by seven, because it’s simply too hard to pick Buffalo against anyone by more than a touchdown based on the Jekyll and Hyde act of Rex Ryan-coached teams.
Andre: 49ers. Sometimes you have to say something out loud to see if it sounds reasonable. When you say, “The Buffalo Bills will win four consecutive games” out loud it sounds a little crazy, doesn’t it? Especially when you consider they have to cover a more-than-a-touchdown spread. I think a pumped-up Colin Kaepernick leads San Francisco to a surprising blowout victory.

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Thumbnail photo via John Hefti/USA TODAY Sports Images

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