College Football Odds: Louisville Favored By Huge Margin Vs. Boston College

After failing to crack the top four in this season’s first College Football Playoff rankings, the Louisville Cardinals will try to post a decisive victory Saturday when they take on the Boston College Eagles as 24 1/2-point favorites at sportsbooks monitored by

Louisville debuted at No. 7 in this week’s rankings despite sporting a 7-1 straight-up record and leading the nation in points per game heading into Saturday afternoon’s Cardinals vs. Eagles betting matchup at Alumni Stadium.

However, the Cardinals fell well short of their average point production in their last outing, topping Virginia 32-25 but failing to cover as 34-point chalk to drop to 1-3 against the spread in their past four contests.

The Eagles are riding high following a 21-14 upset of North Carolina State last weekend, shocking the Wolfpack as 16-point road underdogs to end a two-game SU and ATS slide. Boston College owns a much-improved 4-4 overall record but is just 1-4 SU in conference play this season, and has dropped six straight to nationally ranked opponents.

Boston College also has lost three straight SU to the Cardinals but covered as seven-point road underdogs in a 17-14 loss last season.

While the Cardinals battle to keep their CFP hopes alive, the 8-0 Clemson Tigers look to close the gap on top-ranked Alabama when they host the Syracuse Orange as 26-point favorites.

No. 2 Clemson is one of just five remaining undefeated teams in the nation this season, extending its SU win streak in regular-season action to 23 games. However, the Tigers are winless ATS in their past two games and just 3-2 ATS as double-digit favorites.

The Orange are coming off a bye riding a two-game SU and ATS win streak and are 2-1 SU and ATS on the road this year. Syracuse is winless in three straight against the Tigers but has gone 2-1 ATS, including in its last visit to Clemson two years ago when it covered as 16 1/2-point underdogs in a 16-6 loss.

In other ACC Week 10 betting action, No. 19 Virginia Tech aims for a third straight win as it visits Duke as 11 1/2-point chalk. The Hokies have SU wins in two of three road games, while the Blue Devils have lost two straight but have covered in their past three.

Also, No. 21 North Carolina hosts Georgia Tech as 10 1/2-point chalk, No. 22 Florida State visits the struggling Wolfpack as a 5 1/2-point favorite, the Cavaliers visit Wake Forest as three-point underdogs and Miami welcomes Pittsburgh to town as a three-point favorite.

Thumbnail photo via Geoff Burke/USA TODAY Sports Images

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