MLB Odds: Red Sox Heavy Favorites Vs. Orioles At Fenway Park

The Boston Red Sox will be looking to claim their first series victory over the Baltimore Orioles on home turf since September 2015 when they open a four-game set Friday as -215 favorites on the MLB odds at sportsbooks monitored by

Boston took two of three games from the New York Yankees with Thursday’s 6-3 win as a +104 underdog, extending its lead atop the AL East standings to 2.5 games going into Friday night’s Orioles vs. Red Sox betting matchup. However, the Red Sox regularly have struggled when Baltimore comes to town, losing four straight home dates and going 6-12 in the past 18 meetings between the division rivals at Fenway Park.

Offensive production has been a glaring problem for the Red Sox during their ongoing home swoon against Baltimore. The club has been outscored by a wide 33-7 margin in four consecutive home losses to the Orioles and held to three or fewer runs in nine of their past 18 games.

However, the Red Sox have had little difficulty running up the score with regularity during the first week of the campaign, scoring seven or more runs in five of their past eight outings and averaging nine runs per game over their past five, spurring a 4-1 run for the OVER in totals betting according to the OddsShark MLB Database.

The 5-8 Orioles travel to Boston after avoiding the sweep in a three-game series against the visiting Toronto Blue Jays with a 5-3 victory Wednesday night as -131 favorites.

Baltimore has struggled with consistency during the first two weeks of the campaign. The Orioles eked out just two total runs in a pair of losses to Toronto earlier this week and have been held to two or fewer runs in six of their first 13 outings. Baltimore has also been shut out in its past two matchups against the Red Sox, both on home turf, including a lopsided 9-0 defeat as a +220 underdog on September 20.

Southpaw Eduardo Rodriguez will try to rebound from a shaky performance in his first start of the season when he takes the hill Friday for the Red Sox, while Baltimore counters with veteran righthander Chris Tillman.

Rodriguez failed to earn the decision April 8 in Boston’s 8-7 win over Tampa Bay as a -193 home bet and has allowed 12 total earned runs in 12.1 innings while taking the loss in each of his past two starts against the Orioles.

Tillman has surrendered nine earned runs over 9.1 innings while getting tagged with two losses so far this season but he sports a 10-4 record in 21 career starts against Boston.

Thumbnail photo via Greg M. Cooper/USA TODAY Sports Images

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