The San Francisco 49ers and franchise quarterback Jimmy Garoppolo struggled mightily last week in a season-opening loss to the Minnesota Vikings on the road, but their Week 2 matchup Sunday is a lot more favorable.

The Detroit Lions are in San Francisco to take on the 49ers, and their defense must improve substantially after giving up 48 points in an embarrassing loss to the New York Jets on “Monday Night Football.”

Here’s how and when to watch 49ers vs. Lions:

Start Time: Sunday, Sept. 16 at 4:05 p.m. ET
TV Channel: FOX
Live StreamYahoo! Sports | FuboTV

Thumbnail photo via Stan Szeto/USA TODAY Sports Images