The New York Giants will head to New England as massive underdogs against the Patriots on Thursday night.

And that’s before taking a look at the Giants’ injury report.

New York could be without a number of key offensive pieces, essentially handing the Pats another preseason-like matchup as the season moves past a third of the way through the schedule.

Giants wide receiver Sterling Shepard was placed in concussion protocol Monday, which likely will make him unavailable for the Week 6 matchup, according to NFL Media’s Ian Rapoport.

Saquon Barkley is hopeful he can suit up against the Patriots for “Thursday Night Football,” but even so, his use likely will be limited.

The Giants did not practice Monday, but released an injury report that is rather concerning for New York fans.

Backup running back Wayne Gallman, who has filled in somewhat admirably in Barkley’s absence, also was listed on the injury report with a concussion, while tight end Evan Engram was listed with a knee injury.

Engram tops the Giants in targets with 48, while Shepard follows with 35. If New York does not have either of those options, even if Barkley suits up, it certainly will hinder Big Blue’s chances at moving the ball against the Patriots dominant, albeit rather untested defense.

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