According to The Boston Globe, Buchholz made his television debut on Comedy Central's Tosh.O on Wednesday.
Buchholz portrayed a pitcher facing off against comedian Daniel Tosh. The Red Sox right-hander enjoyed making the skit.
"It was fun," Buchholz told the Globe. "It wasn't like I had to do much acting. I just had to throw a few pitches."
The 25-year-old also will appear in a SportsCenter commercial for ESPN that will reportedly air around Opening Day.