Dustin Pedroia slides into the cleanup spot as the Red Sox open a three-game series Monday against the Minnesota Twins.
Carl Crawford moves into the No. 2 spot in the order for Pedroia, who replaces Kevin Youkilis in the middle of the order. Jed Lowrie bats eighth and will play third base.
Tim Wakefield (6-4, 4.99 ERA) will take the ball for the Red Sox, who will face 29-year-old right-hander Scott Baker (8-6, 3.01).
First pitch is scheduled for 7:10 p.m. Eastern Time.
Here are the complete lineups for both teams:
Red Sox
Jacoby Ellsbury, CF
Carl Crawford, LF
Adrian Gonzalez, 1B
Dustin Pedroia, 2B
David Ortiz, DH
Jarrod Saltalamacchia, C
Josh Reddick, RF
Jed Lowrie, 3B
Marco Scutaro, SS
Twins
Denard Span, CF
Trevor Plouffe, 2B
Joe Mauer, C
Michael Cuddyer, 1B
Jason Kubel, RF
Jim Thome, DH
Danny Valencia, 3B
Delmon Young, LF
Matt Tolbert, SS