Napoli will play first base and bat cleanup for the Red Sox, who start a three-game road series against the rival Yankees. Brandon Workman will start for Boston after serving his six-game suspension for throwing at Tampa Bay Rays slugger Evan Longoria.
Jonny Gomes will start in left field at Yankee Stadium against New York left-hander Vidal Nuno.
Check out the full Red Sox lineup below.
Boston Red Sox (36-43)
Brock Holt, RF
Dustin Pedroia, 2B
David Ortiz, DH
Mike Napoli, 1B
Jonny Gomes, LF
A.J. Pierzynski, C
Xander Bogaerts, 3B
Stephen Drew, SS
Jackie Bradley Jr., CF
Brandon Workman, RHP (1-0, 2.88 ERA)
New York Yankees (40-37)
Brett Gardner, LF
Derek Jeter, SS
Jacoby Ellsbury, CF
Mark Teixeira, 1B
Carlos Beltran, DH
Brian McCann, C
Brian Roberts, 2B
Ichiro Suzuki, RF
Kelly Johnson, 3B
Vidal Nuno, LHP (1-4, 5.88 ERA)