Terry Francona and Ozzie Guillen are unsurprisingly giving many of their players who participated in Saturday's double-header a rest.
For Sunday's series finale, the lineup cards will look rather different.
Manny Ramirez is out of the ChiSox lineup, and Paul Konerko will move from first base to DH. Veteran Mark Kotsay will take his spot.
Omar Vizquel, who is capable of playing just about anywhere, will be at third base today. The rest of the lineup, though, is pretty standard White Sox fare.
For Boston, J.D. Drew will rest while Darnell McDonald, Bill Hall, and Ryan Kalish make up the outfield. McDonald will lead off in place of Marco Scutaro, who is also out of the lineup.
Yamico Navarro will instead be playing at shortstop. The heart of the Sox lineup though, Victor Martinez, David Ortiz and Adrian Beltre, will remain intact.
Here are the lineups for both teams:
Red Sox
Darnell McDonald, LF
Jed Lowrie, 2B
Victor Martinez, C
David Ortiz, DH
Adrian Beltre, 3B
Mike Lowell, 1B
Bill Hall, RF
Yamico Navarro, SS
Ryan Kalish, CF
White Sox
Juan Pierre, RF
Omar Vizquel, 3B
Alex Rios, CF
Paul Konerko, DH
Carlos Quentin, LF
A.J. Pierzynski, C
Alexei Ramirez, SS
Mark Kotsay, 1B
Gordon Beckham, 2B