Jed Lowrie will again get the start at shortstop, and Jarrod Saltalamacchia will be back behind the plate after a night off, catching for John Lackey.
Lineups for the game are as follows:
Red Sox
Jacoby Ellsbury, CF
Dustin Pedroia, 2B
Adrian Gonzalez, 1B
Kevin Youkilis, 3B
David Ortiz, DH
J.D. Drew, RF
Jed Lowrie, SS
Carl Crawford, LF
Jarrod Saltalamacchia, C
Mariners
Ichiro Suzuki, RF
Chone Figgins, 3B
Milton Bradley, LF
Miguel Olivo, C
Justin Smoak, 1B
Jack Cust, DH
Michael Saunders, CF
Brendan Ryan, SS
Jack Wilson, 2B