After going 2-for-4 and raising his average to .306 in the first half of a day-night doubleheader Sunday, Lowrie sat in the nightcap and then again in the series opener with Chicago on Monday with a sore left shoulder.
Lowrie and left fielder Carl Crawford had collided chasing a fly in that afternoon affair.
Lowrie will settle into the seventh spot in the lineup, behind Crawford and in front of J.D. Drew. Crawford went 9-for-12 with six extra-base hits and seven RBIs in his first three games batting sixth, but is 0-for-11 in three games since.
Not one Boston starter has ever faced White Sox right-hander Phil Humber, who will get the start after a flip-flop with originally scheduled starter Gavin Floyd. Drew Sutton, who will begin this one on the bench, is 0-for-1 with a strikeout vs. Humber.
Jason Varitek is behind the plate and batting ninth. He has a hit in eight straight starts.
Alfredo Aceves is on the mound for Boston. Chicago's starting lineup is a combined 5-for-22 (.227) with no extra-base hits against him.
Here is the complete lineup card for the second of three games between the teams:
Boston
Jacoby Ellsbury, CF
Dustin Pedroia, 2B
Adrian Gonzalez, 1B
Kevin Youkilis, 3B
David Ortiz, DH
Carl Crawford, LF
Jed Lowrie, SS
J.D. Drew, RF
Jason Varitek, C
Chicago
Juan Pierre, LF
Alexei Ramirez, SS
Carlos Quentin, RF
Paul Konerko, 1B
A.J. Pierzynski, C
Alex Rios, CF
Adam Dunn, DH
Gordon Beckham, 2B
Brent Morel, 3B
