Youkilis, who enters hitting .237, will be the DH for the third time this year, giving David Ortiz a rest against left-hander Brian Duensing.
The shift allows Jed Lowrie to move to third base and for Scutaro to get a rare start. It is just the fifth start since April 24 for the veteran shortstop.
Jarrod Saltalamacchia, who has a hit in his one plate appearance vs. Duensing, gets a start in a day game after playing the entirety of the loss Friday night. Carl Crawford, hitting .391 (9-for-23) in May, is batting eighth.
With Clay Buchholz on the mound, here is the Red Sox lineup against Duensing:
Jacoby Ellsbury, CF
Dustin Pedroia, 2B
Adrian Gonzalez, 1B
Kevin Youkilis, DH
Jed Lowrie, 3B
Mike Cameron, RF
Jarrod Saltalamacchia, C
Carl Crawford, LF
Marco Scutaro, SS