It’s been a mostly lopsided competition, though, with Brady and the Patriots winning the majority of the regular-season meetings, in addition to taking four of the teams’ five playoff matchups.
These teams resume their rivalry Sunday in a Week 6 matchup fans of both teams have had circled on their calendar for months.
In the meantime, let’s take a look back into NFL history and view the best moments from the Patriots-Colts rivalry.
Thumbnail photo via David Butler II/USA TODAY Sports Images