Kevin Youkilis remains at first base and will bat fifth while Will Middlebrooks will start at third and bat behind him.
Newcomer Scott Podsednik gets the nod in centerfield and will bat eighth.
Check out the lineups below.
Red Sox
Mike Aviles, SS
Dustin Pedroia, 2B
David Ortiz, DH
Adrian Gonzalez, RF
Kevin Youkilis, 1B
Will Middlebrooks, 3B
Daniel Nava, LF
Scott Podsednik, CF
Kelly Shoppach, C
Daniel Bard, P
Orioles
Xavier Avery, LF
Robert Andino, SS
Nick Markakis, RF
Adam Jones, CF
Chris Davis, 1B
Wilson Betemit, 3B
Nick Johnson, DH
Ryan Flaherty, 2B
Luis Exposito, C
Jake Arrieta, P