The Yankees say they expect the break to heal without surgery. The injury came on the same day the Yankees placed left-hander CC Sabathia on the 15-day disabled list with a strained groin.
Casey Kotchman's low line drive hit Pettitte near his left ankle, the one the left-hander pushes off with. Pettitte took a step after the ball near the third base line before gently dropping to the infield grass.
Pettitte tried to stay in the game, but manager Joe Girardi removed him when he came up limping after throwing one live pitch.
Pettitte (3-3) retired after the 2010 postseason but returned to the Yankees this spring to shore up New York's pitching rotation, which had already lost Michael Pineda at the time to shoulder surgery.
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