Logan Mankins, Brandon Deaderick, Justin Francis and Alfonzo Dennard will join Aaron Hernandez and Julian Edelman on the inactive list on Sunday against the Bills.
That leaves one more player for the team to announce before Sunday's 1 p.m. start time.
With just four active linemen on the roster, there's a good chance recently signed Terrell McClain will get playing time for the Patriots. He would be in a rotation with Vince Wilfork, Kyle Love and Ron Brace in the middle of the Patriots defense trying to stop talented Bills running backs C.J. Spiller and Fred Jackson.
It's possible Patriots fans will be getting their first 2012 look at Shane Vereen on Sunday. The second-year player and former second-round pick has been injured through most of his first two seasons in the league.