The Buffalo Bills will be without their No. 1 receiving threat this Sunday when they visit the New England Patriots at Gillette Stadium.

The Bills ruled wide receiver Sammy Watkins for Sunday’s game as he continues to recover from a foot injury, the team announced Friday.

Bills coach Rex Ryan told reporters there is “major concern” Watkins’ injury could affect his ability for future games.

Watkins played in Buffalo’s first two games but failed to make a significant impact, catching six total passes for 63 yards with zero touchdowns. He was inactive last Sunday as the Bills upset the Arizona Cardinals 33-18 for their first win of the season.

With Watkins sidelined, expect another heavy dose of running back LeSean McCoy, who rushed for 110 yards and two touchdowns on 17 carries against Arizona. Quarterback Tyrod Taylor also enjoyed a strong rushing performance, carrying the ball nine times for 76 yards and one score.

The Patriots enter Sunday’s game 3-0 after dispatching the Cardinals, Miami Dolphins and Houston Texans.

Thumbnail photo via Geoff Burke/USA TODAY Sports Images