Very rarely do the two combine to create a special moment, one that is passed down from generation to generation as a reminder of what makes the ballpark and the rivalry so magical.
Some of them have come in the playoffs, others during the regular season. All of them, however, have been memorable.
Dave Roberts' steal — a.k.a. The Steal — sparked the Red Sox' historic comeback and, eventually, their first World Series in 86 years. But without the moments leading up to it, it might not have had the same significance in Red Sox lore.
Jason Varitek and Alex Rodriguez's fight earlier that year set the tone for that fateful ALCS, fueling the fire of a rivalry that had been smoldering since the year before in 2003. That, of course, would be the same year that Pedro Martinez tossed Don Zimmer to the ground when tempers flared in the playoffs.
And who could forget the fateful one-game playoff in 1978, when Bucky (Effing) Dent's three-run home run lifted the Yankees over the Red Sox and on their way to a World Series title?
Overall, the Red Sox and Yankees have never gone wanting for moments at Fenway Park, and Friday's chapter is a testament to the history between the two teams. Looking back, does any one moment stand out above the others?