With Wade resting on the bench and center Jermaine O'Neal out after being ejected, the Heat went on a 14-3 run to start the final period. James Jones sank a pair of 3-pointers during the spurt, and Jamaal Magloire's running dunk punctuated it to give Miami a 16-point lead.
The Heat won their third consecutive game to start a six-game homestand. They've won six in a row at home, their longest such streak in three seasons.
The 76ers lost their fourth consecutive game, and they're 0-2 against Miami this season.
O'Neal was ejected midway through the third quarter after grabbing Samuel Dalembert's face during a confrontation. The Heat also played a second game in a row without second-leading scorer Michael Beasley, sidelined with a bruised left thigh.
Miami led 73-57 when O'Neal departed, but the 76ers went on a 15-3 run in the final 4:46 of the third quarter to cut the deficit to five points.
Wade took a seat and watched the next six minutes while the Heat rebuilt their lead. He finished 14-for-25 with five rebounds.
Reserve Jason Kapono scored 17 for the 76ers, who kept things close only because they shot 11-for-24 from 3-point range. Jones scored 14 and Udonis Haslem had 13 points and 12 rebounds off the Miami bench. Carlos Arroyo had a season-high 10 assists, 12 points and no turnovers.
O'Neal departed after receiving two technical fouls for his confrontation with Dalembert, who received one technical and remained in the game.
Moments before their altercation, Dalembert accidentally poked O'Neal in the eye under the basket. Following a timeout, the two were running upcourt when their arms tangled. A foul was called on another player, and O'Neal briefly grabbed Dalembert's face with one hand before being pulled away.
Notes
Philadelphia F-C Marreese Speights missed his fourth consecutive game with a right knee sprain. … Miami improved to 31-6 when ahead at halftime. … The 76ers came into the game ranked fourth in the NBA in steals.