Aviles will be the first Boston batter to step up to the plate Sunday, leading things off against Tommy Hunter and the Orioles.
Middlebrooks, meanwhile, returns to the lineup after being scratched on Saturday due to hamstring tightness. He'll bat eighth and play third base.
Jarrod Saltalamacchia will once again be behind the plate, catching Clay Buchholz, who looks to rebound after giving up six runs to Oakland on Monday. He did pick up the win in that contest, though, which is something he'll look to replicate with the Sox in the midst of a four-game skid.
The rest of Sunday's lineups are below.
Red Sox
Mike Aviles, SS
Ryan Sweeney, RF
Dustin Pedroia, 2B
Adrian Gonzalez, 1B
David Ortiz, DH
Cody Ross, LF
Jarrod Saltalamacchia, C
Will Middlebrooks, 3B
Marlon Byrd, CF
Clay Buchholz, P
Orioles
Ryan Flaherty, LF
J.J. Hardy, SS
Nick Markakis, RF
Adam Jones, CF
Matt Wieters, C
Chris Davis, DH
Mark Reynolds, 3B
Nick Johnson, 1B
Robert Andino, 2B
Tommy Hunter, P
