College Football Week 10 Predictions: Picks Against Spread For Top 25 Teams

Week 10 of the college football season features plenty of awesome conference matchups that will have huge implications on next week’s College Football Playoff rankings.

There are two notable games this week. One is a Big Ten battle featuring No. 10 Nebraska going on the road to play No. 6 Ohio State. The other is No. 1 Alabama going west to play No. 13 LSU in a much-anticipated SEC showdown.

Here are my predictions for Week 10. All spreads are from OddsShark, and my picks are italicized.

Season picks record: 85-74-4 (6-9-1 last week)

Thursday, Nov. 3
No. 14 Oklahoma (-21) at Iowa State

Friday, Nov. 4
San Jose State at No. 24 Boise State (-29)

Saturday, Nov. 5
No. 4 Texas A&M (-14) at Mississippi State
No. 7 Louisville (-25.5) at Boston College
No. 8 Wisconsin (-7) at Northwestern
Maryland at No. 3 Michigan (-31)
No. 18 Oklahoma State at Kansas State (-3)
Syracuse at No. 2 Clemson (-26)
No. 19 Virginia Tech (-11) at Duke
TCU at No. 17 Baylor (-8)
No. 11 Florida (-4.5) at Arkansas
Arizona at No. 25 Washington State (-17)
No. 22 Florida State (-6) at North Carolina State
Kansas at No. 20 West Virginia (-34.5)
Iowa at No. 12 Penn State (-7.5)
No. 1 Alabama (-8) at No. 13 LSU
No. 10 Nebraska at No. 6 Ohio State (-16.5)
No. 5 Washington (-16.5) at California

Thumbnail photo via Matt Bush/USA TODAY Sports Images