College Football Odds: Clemson, Louisville Both Huge Favorites In ACC Action

Conference matchups featuring massive spreads dominate the Atlantic Coast Conference schedule this weekend, starting Friday when the Louisville Cardinals host the Duke Blue Devils as 35-point betting favorites at sportsbooks monitored by

Louisville enjoyed a bye last weekend following a 42-36 loss to Clemson that halted the team’s meteoric climb up the rankings, and leaves them with a 4-1 straight-up record ahead of Friday night’s Blue Devils vs. Cardinals betting matchup at Papa John’s Cardinal Stadium.

The Cardinals peaked at No. 3 in the national rankings after opening with four lopsided SU and against-the-spread victories, but fell to No. 7 with their loss to the Tigers.

Duke is coming off a 13-6 win over Army as six-point chalk in a rain-soaked contest last weekend, lifting it to 3-3 SU and ATS on the year. The Blue Devils have performed well as double-digit underdogs, going to 2-2 SU and 3-1 ATS in their past four, but were blown out 40-3 by Louisville in their last meeting in 2002, failing to cover as 17-point underdogs.

The Tigers, meanwhile, look to solidify their position at No. 3 in the rankings as they host the North Carolina State Wolfpack as 17 1/2-point favorites on the college football point spreads. Clemson improved to 6-0 SU with a dominating 56-10 win over Boston College last weekend, and has now surrendered 13 or fewer points in four contests this season.

The Wolfpack escaped with a 10-3 win over Notre Dame last Saturday in a sloppy contest marred by the harsh weather created by Hurricane Matthew. NC State has impressed with four wins in five outings, but has lost 11 of 12 SU to the Tigers and has not posted a SU win at Clemson since 2002.

No. 14 Florida State looks to tally consecutive SU wins against an ACC rival for the first time in a year when it hosts the Wake Forest Demon Deacons as 21-point chalk. The Seminoles escaped with a 20-19 victory over Miami last week, winning outright as 1 1/2-point road underdogs, while Wake Forest improved to 5-1 SU with a 28-9 beating of Syracuse.

The Demon Deacons also kept it close in a 24-16 loss to the Seminoles last October, ending a three-game losing streak against Florida State as double-digit underdogs.

In other ACC betting action this week, No. 17 Virginia Tech looks to improve to 3-0 SU against ACC opponents as it battles the Orange as 19 1/2-point chalk, while the 16th-ranked Hurricanes look to bounce back with a win when they entertain North Carolina as relatively narrow 7 1/2-point chalk.

Thumbnail photo via Stew Milne/USA TODAY Sports Images

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