Bills Vs. Titans Odds: Picks, Preview For ‘Monday Night Football’

Buffalo is a 6-point favorite in this primetime tilt


October 18, 2021

The red-hot Buffalo Bills are set to take center stage as Week 6 of the 2021 NFL concludes.

The Bills on Monday night will host the Tennessee Titans for a battle of current division leaders. Buffalo owns the top spot in the AFC East standings with a 4-1 record, while Tennessee’s 3-2 mark is good enough for the AFC South’s best.

While this matchup isn’t ultra-intriguing, it does offer NFL bettors one last opportunity to take some action before the two-day layoff.

Here’s a Bills-Titans betting preview, courtesy of SportsGrid.

Tennessee Titans at (-6) Buffalo Bills
Moneyline: Bills -260, Titans +215
Spread: Bills -6 (-114), Titans +6 (-106)
Total: 53.5 — Over (-110), Under (-110)

The Bills will have revenge on their mind when they head to Tennessee to take on the Titans on Monday night. Both teams met last season in a unique game the league rescheduled to be played on a Tuesday. The reason for the change was due to a COVID-19 outbreak in the Tennessee locker room.

Nonetheless, the Titans ended up destroying the Bills 42-16. While it was undoubtedly a tough spot for both teams, the Titans looked like a team on a freeroll as no one would’ve criticized them if they lost the game based on the circumstances. As for the Bills, they were in a letdown and look-ahead spot with a home game against the AFC champion Kansas City Chiefs the following week.

Buffalo uncharacteristically turned the ball over three times — twice inside its half — with all three turnovers resulting in touchdown drives that took less than two minutes. Titans cornerback, Malcolm Butler, was responsible for two of those turnovers with two interceptions of Bills quarterback Josh Allen. Butler’s no longer on the Titans and retired before the season due to a personal matter.

This time, the Bills come into this game off an impressive 38-20 road victory over the Chiefs in Week 5.

Buffalo has the highest point differential (+108) in the league, and it’s ranked first in Football Outsiders Overall DVOA metric. I think it’s fair to expect the Titans to establish the run with Derrick Henry in the first half. However, the Bills have done a good job containing him as he’s yet to rush for more than 78 yards in their three meetings.

If Buffalo’s offense plays at the same level that we’ve seen over the last four weeks, that’ll force Tennesee to be more unbalanced and abandon the run. Thus, the Titans will likely be chasing the game, particularly in the second half.

That could play right into the hands of a Bills defense ranked first in DVOA against the pass.

The Bills are 9-1 ATS in the second half of their past ten games. They’re also on a 4-0 ATS run in this spot. This game sets up well for them, and I think it’s worth laying the points in the second half.

All NFL game predictions and picks are courtesy of SportsGrid.

Thumbnail photo via Christopher Hanewinckel/USA TODAY Sports Images

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