The NFL and the Jags announced Tuesday that the team will play one home game in London for four years in a row.
NFL Commissioner Roger Goodell and team owner Shad Khan made a joint announcement about the move in Jacksonville. The small-market franchise will play four games at Wembley Stadium, one every season beginning in 2013.
Khan has made it clear he wants to play games overseas in hopes of increasing the team's brand globally.
The NFL has played an annual London game since 2007. New England and St. Louis play at Wembley later this year.
The Rams had been scheduled to play in London in 2013 and 2014, but they pulled out last week, citing a need to focus on lease negotiations and ease fan discontent.